[1] 邱贵兴. 骨质疏松性骨折-被忽视了的健康杀手[J]. 中华医学杂志, 2005, 85(11): 730-731.
[2] Coipeau P, Rosset P, Langonne A,et al.Impaired differentiation potential of human trabecular bone mesenchymal stromal cells from elderly patients.Cytotherapy. 2009;11(5):584-594.
[3] Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects.J Clin Invest. 2005;115(12):3318-3325.
[4] Weinstein RS, Manolagas SC.Apoptosis and osteoporosis. Am J Med. 2000;108(2):153-164.
[5] Cho SW, Sun HJ, Yang JY,et al.Transplantation of mesenchymal stem cells overexpressing RANK-Fc or CXCR4 prevents bone loss in ovariectomized mice.Mol Ther. 2009; 17(11):1979-1987.
[6] 吕厚辰,唐佩福.胎球蛋白A 在骨矿化早期的抑制作用[J].解放军医学院学报,2013,34(1): 98-100.
[7] Canalis E, Giustina A, Bilezikian JP.Mechanisms of anabolic therapies for osteoporosis.N Engl J Med. 2007;357(9): 905-916.
[8] Levi B, Longaker MT.Concise review: adipose-derived stromal cells for skeletal regenerative medicine.Stem Cells. 2011;29(4):576-582.
[9] Deschaseaux F, Sensébé L, Heymann D. Mechanisms of bone repair and regeneration.Trends Mol Med. 2009;15(9): 417-429.
[10] 赵铭,李博.骨形态生发蛋白2基因修饰脂肪干细胞对去卵巢骨质疏松性大鼠骨缺损的修复作用[J].中国骨质疏松杂志, 2012, 18(8):706-708.
[11] Dragoo JL, Lieberman JR, Lee RS,et al.Tissue-engineered bone from BMP-2-transduced stem cells derived from human fat.Plast Reconstr Surg. 2005;115(6):1665-1673.
[12] Levi B, James AW, Nelson ER,et al. Human adipose derived stromal cells heal critical size mouse calvarial defects.PLoS One. 2010;5(6):e11177.
[13] Levi B, Hyun JS, Nelson ER,et al.Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair.Stem Cells. 2011; 29(12):2018-2029.
[14] Zhang X, Guo J, Zhou Y,et al.The roles of bone morphogenetic proteins and their signaling in the osteogenesis of adipose- derived stem cells.Tissue Eng Part B Rev. 2014;20(1):84-92.
[15] Marie PJ.Fibroblast growth factor signaling controlling osteoblast differentiation.Gene. 2003;316:23-32.
[16] Quarto N, Longaker MT.FGF-2 inhibits osteogenesis in mouse adipose tissue-derived stromal cells and sustains their proliferative and osteogenic potential state.Tissue Eng. 2006; 12(6):1405-1418.
[17] Kwan MD, Sellmyer MA, Quarto N,et al.Chemical control of FGF-2 release for promoting calvarial healing with adipose stem cells.J Biol Chem. 2011;286(13):11307-11313.
[18] Quarto N, Wan DC, Longaker MT.Molecular mechanisms of FGF-2 inhibitory activity in the osteogenic context of mouse adipose-derived stem cells (mASCs).Bone. 2008;42(6):1040- 1052.
[19] Marie PJ.Fibroblast growth factor signaling controlling bone formation: an update.Gene. 2012;498(1):1-4.
[20] Artavanis-Tsakonas S, Rand MD, Lake RJ.Notch signaling: cell fate control and signal integration in development.Science. 1999;284(5415):770-776.
[21] Afelik S, Qu X, Hasrouni E,et al.Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells. Development. 2012;139(10):1744-1753.
[22] Jeon SJ, Fujioka M, Kim SC, et al.Notch signaling alters sensory or neuronal cell fate specification of inner ear stem cells.J Neurosci. 2011;31(23):8351-8358.
[23] Ugarte F, Ryser M, Thieme S,et al.Notch signaling enhances osteogenic differentiation while inhibiting adipogenesis in primary human bone marrow stromal cells.Exp Hematol. 2009; 37(7):867-875.
[24] Tu X, Chen J, Lim J,et al. Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.PLoS Genet. 2012;8(3):e1002577.
[25] Hilton MJ, Tu X, Wu X,et al.Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation.Nat Med. 2008;14(3):306-314.
[26] Tezuka K, Yasuda M, Watanabe N,et al.Stimulation of osteoblastic cell differentiation by Notch.J Bone Miner Res. 2002;17(2):231-239.
[27] Deregowski V, Gazzerro E, Priest L,et al. Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling.J Biol Chem. 2006;281(10):6203-6210.
[28] Zamurovic N, Cappellen D, Rohner D,et al.Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity.J Biol Chem. 2004;279(36): 37704-37715.
[29] Davis LA, Zur Nieden NI.Mesodermal fate decisions of a stem cell: the Wnt switch.Cell Mol Life Sci. 2008;65(17): 2658-2674.
[30] Baron R, Kneissel M.WNT signaling in bone homeostasis and disease: from human mutations to treatments.Nat Med. 2013; 19(2):179-192.
[31] Krishnan V, Bryant HU, Macdougald OA.Regulation of bone mass by Wnt signaling.J Clin Invest. 2006;116(5):1202-1209.
[32] Mason JJ, Williams BO.SOST and DKK: Antagonists of LRP Family Signaling as Targets for Treating Bone Disease.J Osteoporos. 2010;2010. pii: 460120.
[33] Gaur T, Wixted JJ, Hussain S,et al.Secreted frizzled related protein 1 is a target to improve fracture healing.J Cell Physiol. 2009;220(1):174-181.
[34] Bennett CN, Longo KA, Wright WS,et al.Regulation of osteoblastogenesis and bone mass by Wnt10b.Proc Natl Acad Sci U S A. 2005;102(9):3324-3329.
[35] Cui Y, Niziolek PJ, MacDonald BT,et al. Lrp5 functions in bone to regulate bone mass.Nat Med. 2011;17(6):684-691.
[36] Wang J, Liu B, Gu S,et al.Effects of Wnt/β-catenin signalling on proliferation and differentiation of apical papilla stem cells. Cell Prolif. 2012;45(2):121-131.
[37] Kang S, Bennett CN, Gerin I,et al.Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma.J Biol Chem. 2007;282(19):14515-14524.
[38] Yang F, Yang D, Tu J,et al.Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt/catenin signaling.Stem Cells. 2011;29(6):981-991.
[39] 龚文颖,曾林祥.DAPT对肺成纤维细胞表型转化中Wnt信号通路的影响[J].实用医学杂志,2013,29(2):184-186.
[40] Bertrand FE, Angus CW, Partis WJ,et al.Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch.Cell Cycle. 2012;11(23):4344-4351.
[41] Itasaki N, Hoppler S.Crosstalk between Wnt and bone morphogenic protein signaling: a turbulent relationship.Dev Dyn. 2010;239(1):16-33.
[42] Eyckmans J, Roberts SJ, Schrooten J,et al.A clinically relevant model of osteoinduction: a process requiring calcium phosphate and BMP/Wnt signalling.J Cell Mol Med. 2010; 14(6B):1845-1856.
[43] Zhang R, Oyajobi BO, Harris SE, et al.Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts.Bone. 2013;52(1):145-156.
[44] Rawadi G, Vayssière B, Dunn F,et al.BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop.J Bone Miner Res. 2003;18(10):1842-1853.
[45] Deregowski V, Gazzerro E, Priest L,et al. Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling.J Biol Chem. 2006;281(10):6203-6210.
[46] Tezuka K, Yasuda M, Watanabe N, et al.Stimulation of osteoblastic cell differentiation by Notch.J Bone Miner Res. 2002;17(2):231-239.
[47] Nobta M, Tsukazaki T, Shibata Y,et al.Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling. J Biol Chem. 2005;280(16):15842-15848.
[48] Fakhry A, Ratisoontorn C, Vedhachalam C,et al.Effects of FGF-2/-9 in calvarial bone cell cultures: differentiation stage-dependent mitogenic effect, inverse regulation of BMP-2 and noggin, and enhancement of osteogenic potential. Bone. 2005;36(2):254-266.
[49] Hughes-Fulford M, Li CF.The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization.J Orthop Surg Res. 2011;6:8.
[50] Naganawa T, Xiao L, Coffin JD, et al.Reduced expression and function of bone morphogenetic protein-2 in bones of Fgf2 null mice.J Cell Biochem. 2008;103(6):1975-1988.
[51] Choi KY, Kim HJ, Lee MH,et al. Runx2 regulates FGF2-induced Bmp2 expression during cranial bone development.Dev Dyn. 2005;233(1):115-121.
[52] Wagner W, Wein F, Seckinger A,et al. Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood.Exp Hematol. 2005;33(11):1402-1416.
[53] Gir P, Oni G, Brown SA,et al.Human adipose stem cells: current clinical applications.Plast Reconstr Surg. 2012;129(6): 1277-1290.
[54] Utsunomiya T, Shimada M, Imura S,et al.Human adipose-derived stem cells: potential clinical applications in surgery.Surg Today. 2011;41(1):18-23.
[55] Ahn HH, Kim KS, Lee JH, et al. In vivo osteogenic differentiation of human adipose-derived stem cells in an injectable in situ-forming gel scaffold. Tissue Eng Part A. 2009;15(7):1821-1832.
[56] Zhu Y, Liu T, Song K, et al.Adipose-derived stem cell: a better stem cell than BMSC.Cell Biochem Funct. 2008;26(6): 664-675.
[57] Zhu M, Kohan E, Bradley J,et al.The effect of age on osteogenic, adipogenic and proliferative potential of female adipose-derived stem cells.J Tissue Eng Regen Med. 2009; 3(4):290-301.
[58] Chen HT, Lee MJ, Chen CH, et al.Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures. J Cell Mol Med. 2012;16(3):582-593.
[59] Fossett E, Khan WS, Longo UG,et al. Effect of age and gender on cell proliferation and cell surface characterization of synovial fat pad derived mesenchymal stem cells.J Orthop Res. 2012;30(7):1013-1018.
[60] Peptan IA, Hong L, Mao JJ.Comparison of osteogenic potentials of visceral and subcutaneous adipose-derived cells of rabbits.Plast Reconstr Surg. 2006;117(5):1462-1470.
[61] Valeri CR, Pivacek LE.Effects of the temperature, the duration of frozen storage, and the freezing container on in vitro measurements in human peripheral blood mononuclear cells. Transfusion. 1996;36(4):303-308.
[62] Oishi K, Noguchi H, Yukawa H,et al.Cryopreservation of mouse adipose tissue-derived stem/progenitor cells.Cell Transplant. 2008;17(1-2):35-41.
[63] Thirumala S, Gimble JM, Devireddy RV.Cryopreservation of stromal vascular fraction of adipose tissue in a serum-free freezing medium.J Tissue Eng Regen Med. 2010;4(3): 224-232.
[64] James AW, Levi B, Nelson ER,et al.Deleterious effects of freezing on osteogenic differentiation of human adipose-derived stromal cells in vitro and in vivo.Stem Cells Dev. 2011;20(3):427-439.
[65] Sándor GK, Tuovinen VJ, Wolff J,et al.Adipose stem cell tissue-engineered construct used to treat large anterior mandibular defect: a case report and review of the clinical application of good manufacturing practice-level adipose stem cells for bone regeneration.J Oral Maxillofac Surg. 2013; 71(5):938-950.
[66] Lee JM, Jung J, Lee HJ,et al.Comparison of immunomodulatory effects of placenta mesenchymal stem cells with bone marrow and adipose mesenchymal stem cells.Int Immunopharmacol. 2012;13(2):219-224.
[67] 朱希山,台卫平,施薇,等.骨髓和脂肪来源间充质干细胞的免疫调节作用[J].中国组织工程研究与临床康复, 2011,15(36): 6683-6686.
[68] Liu G, Zhang Y, Liu B,et al.Bone regeneration in a canine cranial model using allogeneic adipose derived stem cells and coral scaffold.Biomaterials. 2013;34(11):2655-2664.
[69] Cao L, Liu G, Gan Y,et al.The use of autologous enriched bone marrow MSCs to enhance osteoporotic bone defect repair in long-term estrogen deficient goats.Biomaterials. 2012;33(20):5076-5084.
[70] Tao H, Yu MC, Yang HY,et al.Effect of allogenic adipose-derived stem cell transplantation on bone mass in rats with glucocorticoid-induced osteoporosis.Nan Fang Yi Ke Da Xue Xue Bao. 2011;31(5):817-821.
[71] You L, Pan L, Chen L,et al.Suppression of zinc finger protein 467 alleviates osteoporosis through promoting differentiation of adipose derived stem cells to osteoblasts.J Transl Med. 2012;10:11.
[72] 闻重秋.脂肪源干细胞移植治疗骨质疏松及其成骨分化蛋白质谱构建[D].广州:南方医科大学,2012.
[73] 李冬松.VEGF基因修饰脂肪干细胞对糖尿病骨质疏松性骨缺损修复作用的研究[D].长春:吉林大学,2008.
[74] 汪玉海,金丽娟,高俊,等.脂肪干细胞复合PLGA对骨质疏松骨折愈合后生物力学的影响[J].宁夏医科大学学报,2013,35(3): 244-247.
[75] Ye X, Zhang P, Xue S,et al. Adipose-derived stem cells alleviate osteoporosis by enchancing osteogenesis and inhibiting adipogenesis in a rabbit model. Cytotherapy. 2014 . [Epub ahead of print]
[76] Liu HY, Chiou JF, Wu AT,et al.The effect of diminished osteogenic signals on reduced osteoporosis recovery in aged mice and the potential therapeutic use of adipose-derived stem cells.Biomaterials. 2012;33(26):6105-6112.
[77] Lee K, Kim H, Kim JM,et al.Systemic transplantation of human adipose-derived stem cells stimulates bone repair by promoting osteoblast and osteoclast function.J Cell Mol Med. 2011;15(10):2082-2094. |